Although an anime’s overall quality is important, the focus is on its implementation of the overpowered protagonist concept. Also, series like Mushoku Tensei have been excluded since Rudy is powerful but not OP.
Updated on June 14, 2025 by Mark Sammut: Isekai anime with overpowered protagonists are not going away anytime soon. The Summer 2025 season will probably have a couple of candidates, with Apocalypse Bringer Mynoghra and The Water Magician being the most obvious candidates. While waiting for the new shows to debut, a few other OP MC isekai anime have been added as recommendations.
13
Arifureta: From Commonplace to World’s Strongest
The Rocky Road To Becoming OP
Arifureta is not the easiest isekai anime to recommend, just because the adaptation gets off to a notoriously underwhelming start. Even though the sequel seasons are better, they do not come close to replicating the quality of the light novel or manga, making the anime the worst way to experience Hajime’s story. That said, if somebody is specifically craving an OP MC isekai anime, Arifureta is among the most mainstream and well-known representatives.
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After being left to die by his schoolmates in a fantasy world’s dungeon, Hajime powers through, all the while striking a (close) friendship with a vampire named Yue. Utilizing magic along with weapons like guns, Hajime quickly builds up a versatile arsenal of abilities that allow him to overwhelm most enemies without breaking a sweat, and he is constantly getting stronger. He also surrounds himself with characters (mainly girls) who can hold their own in battle.
12
My Instant Death Ability is So Overpowered, No One in This Other World Stands a Chance Against Me!
The Ultimate OP MC Isekai Anime…That Is Not Great
My Instant Death Ability was seemingly designed for people who hate overpowered isekai protagonists. A class gets summoned to another world by a manipulative sage, and most of them are given powers. The students who are not bestowed gifts are left for dead; however, one of them, Yogiri, arrived pre-installed with the ability to kill anything with a single thought. Alongside a girl, he goes on a relaxed adventure that primarily involves killing off isekai tropes before they have an opportunity to do anything. Yogiri is unquestionably the most powerful isekai anime MC of all time, and it is not particularly close. Consequently, My Instant Death Ability warrants a mention, despite the anime being relatively underwhelming and repetitive. Still, if somebody is craving a somewhat mean-spirited parody of the genre, this show should deliver.
11
No Game, No Life
The Ultimate Gamers
Sora and Shiro are, in-universe, overpowered. They are specifically brought to Disboard, a world where everything is decided through games, because they are recognized as god gamers who can never be beaten. As a god who looks down on humans, Tet challenges Sora and Shiro to prove that their capabilities go beyond just online gaming, and they are 100% up to the challenge. Now, No Game, No Life is not a conventional OP MC story since the protagonists are constantly pushed to their limits and, more importantly, they do not have incredible abilities. Sora and Shiro rely on their intelligence and experience, allowing them to outsmart their opponents.
10
Kuma Kuma Kuma Bear
An OP Isekai MC (With OP Equipment)
Usually, isekai protagonists receive gifts when they arrive in their new worlds. In the case of Kuma Kuma Kuma Bear’s Yuna, the OP gift is the reason she ends up stuck in an MMO. After accepting a unique bear-themed armor, Yuna finds herself trapped in World Fantasy Online; to make matters worse, she cannot remove her embarrassing outfit. However, the armor has such high stats that Yuna is basically rendered undefeatable, and she does not hesitate to show off her glorious strength.
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Although not devoid of action, Kuma Kuma Kuma Bear is primarily a slice of life comedy. The characters are likable, the visuals are decent enough, and the story maintains a lighthearted and fluffy tone.
9
I’ve Been Killing Slimes For 300 Years And Maxed Out My Level
A Cute Girl Doing OP MC Things
In theory, isekai anime with OP MCs sound like they should prioritize action to take advantage of the protagonist’s cool abilities. However, this concept lends itself surprisingly well to slow-life stories, as the appeal comes from the character having the necessary tools to lead a completely carefree life. I’ve Been Killing Slimes for 300 Years and Maxed Out My Level is among the best examples of this particular subcategory. After grinding slimes for 300 years, Azusa has effectively become a goddess who is by far the most powerful being in this universe. While she occasionally gets involved in fights, Azusa mostly spends her days in paradise, living alongside other girls who admire or rely on her.
8
Uncle From Another World
The OP Isekai Life Is Not All Sunshine And Rainbows
Most isekai anime are escapist fantasies that try to feature a protagonist who is easy for audiences to insert themselves into. Uncle From Another World takes a bit of a different approach. Set after Yousuke returns from an isekai trip that lasted for more than a decade, the anime follows his attempts to settle back onto Earth, all the while incorporating flashbacks to his past adventures.
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Despite being very much OP, Yousuke hated his time in the other world as he was constantly discriminated against. He led a lonely and exhausting existence, one made worse by his inability to recognize a tsundere elf’s interest in him. Uncle From Another World is a hilarious comedy that parodies isekai anime with overpowered protagonists, while also trying out quite a few loving references to pop culture of yesteryear.
7
Villainess Level 99: I May Be the Hidden Boss but I’m Not the Demon Lord
Best Isekai Villainess Anime With An OP MC
Over the last few years, villainess isekai anime have become very common, with most seasons including one show that fits the theme. While always competent, the protagonists of these series are not typically extremely overpowered, and they are usually just strong enough to hold their own. Villainess Level 99 is an exception. Reincarnated as an otome game’s secret hidden boss, Yumiella puts to shame everyone else in this universe, and she spent her childhood grinding to ensure she would be as powerful as possible. She summons a black hole at one point, and she makes it seem effortless. Not fully grasping how off-putting her displays of power can be, Yumiella has an endearing and charming awkwardness. While nothing too amazing, Villainess Level 99 is consistently funny and cute.
6
Zenshu
The Power Of Creativity
A rare original isekai anime, Zenshu almost comes across like a love letter to classic fantasy, particularly shows from the ’80s and ’90s. A talented animator suffering from burnout, Natsuko Hirose chokes on some food and ends up in the world of her favorite anime movie. Hoping to avoid the story’s notoriously depressing ending, Natsuko uses her newfound god-like power to bring to life anything that she draws, and she has a pretty wild imagination. Starting strong and only getting better from there, Zenshu blends genres, tropes, and even visual styles to tell an epic tale that manages to remain fresh despite taking inspiration from the past. While OP in theory, Natsuko’s powers have well-defined limitations, both in terms of mechanics and user error.
5
Tsukimichi -Moonlit Fantasy-
A Well-Rounded Isekai Anime
One of the best isekai anime of the 2020s, Tsukimichi is very close to being the complete package, even if it might not quite reach the genre’s absolute pinnacle. With likable characters, decent action, solid world-building, and better-than-average humor, Tsukimichi is just an all-around enjoyable fantasy show that should be watched even by people who are not particularly into isekai.
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The protagonist, Makoto, is a big reason why the story works as well as it does. While extremely powerful by most standards, he is constantly learning how to better control his abilities, so there is a sense of development that is frequently absent in OP MC isekai anime. Beyond that, Makoto has a few clever weaknesses and blind spots that are covered by the supporting characters; in fact, Tsukimichi gradually becomes more of an ensemble cast anime.
4
Ishura
Let The Overpowered Characters Fight
Ishura
Release Date
January 3, 2024
Directors
Yuki Ogawa, Takeo Takahashi
Writers
Keiso, Kenta Ihara
Ishura’s selling point is simple: Overpowered characters fight to the death. The storytelling can be a touch confusing at times, but the anime ultimately boils down to a series of battles pitting ridiculously powerful warriors against each other. The roster is diverse too (spoiler: there are two mechs), but the variety makes narrative sense as quite a few characters are Visitors from another world. Now, Ishura’s first season has a habit of pushing away viewers since the first few episodes are disjointed. The anime, essentially, starts with a roll call that goes through the major players that will take part in an upcoming war, with each character having roughly half an episode dedicated to them. While messy, this section paves the way to a fantastic second half and an even better season 2.
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